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PD with Non-Motor Symptoms | TOPAZ Study - National Institutes of Health

Trial of Parkinson's and Zoledronic Acid


Did you know that people with Parkinson's disease (PD) have a higher risk of fractures? The TOPAZ study will test if a medicine called zoledronic acid can prevent fractures in people with PD. A team of doctors who are experts in bone health and PD are leading the study. The use of zoledronic acid in this study is investigational.

Full Title

TOPAZ: Trial of Parkinson's And Zoledronic Acid A Randomized Placebo-controlled Trial of Zoledronic Acid for the Prevention of Fractures in Patients With Parkinson's Disease


Currently Enrolling

You can join if:

  • You have Parkinson's disease
  • Are 65 year old or older

What does participation involve?

  • The study is done from your home!
  • If you are eligible for the study, a nurse will come to your home to give you a short exam.
  • You'll receive a one-time dose of either zoledronic acid or a placebo
  • During the study, we will contact you every four months to check if you have had any new fractures

Earn $100 upon enrollment and $50 per year during the study.

Want to learn more about joining TOPAZ? Call the Parkinson's Foundation Helpline at 1-800-4PD-INFO (473-4636).

Ready to enroll? Visit and enter FOUNDATION as your invitation code.

This study is endorsed by the Parkinson's Foundation and the Parkinson's Study Group.

Trial Phase

Phase 4 ID


Principal Investigator(s)
Pinky Agarwal, MD

Clinical Trial Categories

  • Parkinson's Disease
EvergreenHealth Research Services at 425-899-5385


  • EvergreenHealth Clinical Trials
    12039 NE 128th Street, Suite 300
    Kirkland, WA 98034
    Main: 425-899-5385

Contact Us

Call us at (425) 899-5385 or use our online information request form.

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