Essential Tremor with Uncontrollable Hand Movement Trial

The goal of this study is to assess the safety & effectiveness of a new wrist device worn to ease common symptoms of essential tremor over a three-month period, particularly uncontrollable hand movement. The device is called Cala TWO, and is worn on the wrist, much like a fitness tracker bracelet.

Am I eligible to participate?

Eligible participants will meet the following criteria at minimum. However, we encourage you to connect with our research team to determine whether this trial is a fit for you, and to explore other trial opportunities that may align with your health goals and care plan.

  • Age 22 or older
  • Hand tremors due to essential tremor
  • Moderate to severe hand tremors in the dominant hand
  • No implanted electrical medical device, such as a pacemaker, defibrillator, or deep brain stimulator
  • No previous brain surgery for the treatment of tremor
  • No suspected or diagnosed epilepsy or other seizure disorder
  • No implanted metal in your dominant wrist
  • No nerve problems affecting the dominant hand
  • No other neurodegenerative disease (e.g. Parkinson’s, Alzheimer’s, etc.)
  • No Botox for hand tremor within 6months prior to study entry
  • No participation in another interventional clinical trial within 30days of study entry
  • Not pregnant or anticipating pregnancy during the course of the study
  • No diagnosed alcoholism

What does participation involve?

Participants will:

  • Attend three office visits, each lasting between 1-3 hours
  • Receive two scheduled phone call check-ins from your site’s study staff
  • Use the study device (an investigational, body-worn device) at home for three months to see if it may help with your hand tremor symptoms
  • Participants will be compensated for their time

Trial Investigator:  Pinky Agarwal, MD 

If you’re interested in enrolling, please submit this brief form, and a member of our research team will contact you.

You’re also welcome to contact the research team directly at 425.899.5385 or We look forward to discussing your participation and answering your questions.

Learn more about research at EvergreenHealth

See all current Essential Tremor Trials

Directions to EvergreenHealth Research Services