Buproprion SR (Zyban or Wellbutrin)


  • Set a date to stop smoking
  • Begin Buproprion SR one week (7 – 10 days) before your quit date.

Buproprion SR is not recommended if you:

  • Have a seizure disorder
  • Currently have or have had an eating disorder
  • Are currently taking medication for depression
  • Are pregnant, thinking about becoming pregnant, or are breast feeding

How to take Buproprion SR

  1. Take one 150 mg tablet in the morning for three days
  2. On day 4 start taking one 150 mg tablet in the morning and one in the early evening *Make sure doses are at least 8 hours apart
  3. Continue taking Buproprion SR twice a day for 12 weeks or as long as your doctor prescribes.

Important Considerations

  • Never take an extra dose of Buproprion SR. If you forget to take a dose don’t take a “catch-up” dose.
  • Buproprion SR and nicotine patches, gum, and/or lozenges can be used at the same time

Possible Side Effects

  • The most common side effects include: dry mouth, difficulty sleeping, shakiness, and skin rash.
  • Note: These side effects tend to be mild and disappear within the first two weeks
  • Rare incidence of seizures.